Infections caused equipoise definition by sensitive microflora: pneumonia, bronchitis, tracheitis, empyema; cholecystitis, pyelonephritis, intestinal infections; endocarditis, endometritis, prostatitis; syphilis, gonorrhea, whooping cough, brucellosis, typhus, actinomycosis, psittacosis; purulent soft tissue infections; osteomyelitis; trachoma, conjunctivitis, blepharitis; tonsillitis, otitis media, pharyngitis, stomatitis, gingivitis; abrasions, infected eczema, acne, folliculitis.
Hypersensitivity, pregnancy (II-III trimester), lactation, children’s age (up to 8 years), leukopenia. Precautions – Renal Failure.
Dosing and Administration
Inside, drinking plenty of fluids, adults – 0.25-0.5 g 4 times a day, or 0.5-1 g every 12 hours maximum daily dose -. 4 years Children older than 8 years – 6.25-12.5 mg / kg every 6 hours or at 12.5-25 mg / kg every 12 hours When acne:. 0.5-2 g / day in divided doses. In the case of improvement (usually 3 weeks) the dose was gradually reduced to maintenance – 0.125-1 Adequate remission of acne can be achieved when using the drug in a day or intermittent therapy.
Brucellosis – 0.5 g every six hours for three weeks, at the same time with intramuscular streptomycin at 1 g every 12 hours during the first week and 1 time per day during the second week.
Uncomplicated gonorrhea: initial single dose – 1.5 g, followed by 0.5 g every 6 hours for 4 days (total dose of 9 . g)
syphilis – 0.5 g every 6 hours for 15 days (early syphilis) or 30 days (late syphilis).
Uncomplicated urethral, endocervical equipoise definition and rectal infections caused by Chlamydia trachomatis – 0.5 g 4 times a day for at least 7 days .
From the digestive system: anorexia, vomiting, diarrhea, nausea, glossitis, esophagitis, gastritis, ulceration of the stomach and duodenum, the hypertrophy of the papillae tongue, dysphagia, hepatotoxicity, pancreatitis, intestinal dysbiosis, increased activity of “liver” enzymes.
From the nervous system: increased intracranial pressure, toxic effect on the central nervous system (dizziness or imbalance).
From the side of hematopoiesis: hemolytic anemia, thrombocytopenia, neutropenia.
From the urinary system: azotemia, hypercreatininemia.
Allergic and immunopatologocheskie reactions: maculo-papular rash, skin redness , angioedema, anaphylactoid reactions, drug lupus erythematosus, photosensitivity.
Other: superinfection, candidiasis, lack of equipoise definition, hyperbilirubinemia, discoloration of tooth enamel in children.
Interaction with other medicinal products
The absorption reduces antacids containing aluminum, magnesium, calcium, iron supplements, and cholestyramine. In connection with the suppression of intestinal microflora, reducing prothrombin index (requires a dose reduction of indirect anticoagulant).
Reduces the effectiveness of bactericidal antibiotics violating cell wall synthesis (penicillins, cephalosporins).
Chymotrypsin increases the concentration and duration of circulation.
Reduces the estrogensoderjath oral contraceptives and increased risk of bleeding “breakthrough”; Retinol – the risk of increased intracranial pressure.
In connection with the possible development of photosensitivity, you must limit sun exposure. With prolonged use, requires periodic monitoring of renal function, liver, of the blood.
It may mask the symptoms of syphilis, in this connection, with the possibility of mixed infection, you need to monthly serological analysis for 4 months.
All tetracyclines form stable complexes with calcium in any kostnoobrazuyuschey tissue. In this connection, in the reception period of tooth development can cause tooth staining in long yellow-gray-brown color, as well as hypoplasia of enamel.
For preventing hypovitaminosis be administered equipoise definition, brewer’s yeast.