After oral absorption teturama from the gastrointestinal tract equipoise steroid is from 70 to 90%. It is rapidly metabolized, recovering to dithiocarbamate, which itself appears as a glucuronyl conjugate or transformed into diethylamine and carbon sulfide, part of which (4-53%) is output from the light. Maximum therapeutic effect is achieved within 12 hours after oral administration, and may continue for 10-14 days after cessation of treatment.
Treatment and prevention of relapse of chronic alcoholism. As a detoxifying agent for chronic poisoning by nickel.
Hypersensitivity, thyrotoxicosis, diseases of the cardiovascular system in the stage of decompensation (including a pronounced cardio, atherosclerosis of brain vessels, pre- and postinfarction state, aortic aneurysm, coronary insufficiency, hypertension stage II-III), pulmonary equipoise steroid tuberculosis with hemoptysis , bronchial asthma, severe emphysema, erosive lesions of the gastrointestinal mucosa, gastric ulcer and duodenal ulcer (in the acute phase), bleeding from the gastrointestinal tract, kidney disease, liver failure, diabetes mellitus, epilepsy, neuro-psychiatric diseases, infectious diseases, polyneuropathy , neuritis of the auditory and the optic nerve, glaucoma, malignant tumors, pregnancy, lactation.
Precautions – cardiovascular diseases in the stage of compensation, age over 60 years, gastric ulcer and duodenal ulcer (in remission), endarteritis, residual effects of disturbances stroke, psychosis in patients receiving disulfiram history.
Dosage and administration:
Treatment is prescribed after a thorough examination of the patient and the prevention of the consequences and complications. The drug is taken orally by 150-500 mg 2 times a day on an individual scheme.After 7-10 days carried teturamalkogolnuyu sample (20-30 ml of 40% after administration regia 500 mg) is increased to 10-20 ml (maximum dose of 100-120 ml of vodka) with a weak dose response alcohol.The sample is repeated every 1-2 days in the hospital and outpatient 3-5 days correction doses of alcohol and / or drug if necessary. Further it is possible to use a maintenance dose of 150-200 mg per day for 1-3 years.
Side effects caused by properties teturama:
- Metallic taste in the mouth.
- Unpleasant smell in patients with colostomy (associated with carbon sulfide).
- Rare cases of hepatitis, sometimes found in patients with eczema of nickel, not suffering from alcoholism.
- Polyneuritis of lower limbs, neuritis of the optic nerve.
- Loss of memory, heterogeneity of consciousness, fatigue.
- Skin allergic reactions. Related equipoise steroid combination teturam-ethanol: Cases of respiratory failure; cardiovascular collapse, cardiac arrhythmias, angina pectoris, myocardial infarction sometimes, and neurological disorders; . cerebral edema Complications Propafenone: rarely psychosis, resembling alcoholic hepatitis, gastritis; in patients suffering from cardiovascular diseases is possible thrombosis of the brain vessels, so the complaints of paresthesias in the extremities and face, should stop the drug immediately; exacerbation of polyneuritis. When receiving doses of alcohol of more than 50-80 ml of vodka while taking teturama develop severe disorders of the cardiovascular and respiratory systems, edema, convulsions. In this case urgently carried out detoxication therapy, administered analeptics, symptomatic treatment.