Equipoise simultaneous administration of the drug with other non-opioid analgesics can lead to increased toxic effects. Tricyclic antidepressants, contraceptives oral, allopurinol increase the toxicity Metamizole. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken action Metamizole. Sedatives and tranquilizers increase the analgesic  . Adsorbents, binders and overlying means may reduce the absorption of codeine, which is a part of the drug in the gastrointestinal tract. The simultaneous use with cyclosporine reduces the concentration of the latter in the blood plasma. Caffeine accelerates the absorption of ergotamine.

special instructions

The drug should not take more than 5 days in the appointment as an analgesic, and more than 3 days as antipyretic.
With long-term (more than 5 days) use of the drug is necessary to monitor patterns of peripheral blood and functional state of the liver.
The drug may hinder diagnosis in abdominal equipoise pain syndrome, including the “acute” abdomen.
in patients with bronchial asthma, hay fever have an increased risk of developing hypersensitivity reactions. Can change the results of the analyzes of doping control of athletes.
During the administration of the drug is not suitable for excessive use of tea and coffee, as this could lead to agitation, sleep disturbances, tachycardia, cardiac arrhythmias.
With the development of the constant need for taking the drug, it is necessary to address urgently to doctor.
The drug has no effect on the coordination of movements, but not recommended for use in the performance of potentially hazardous activities that require equipoise attention and fast reactions (road management, work with moving machinery, the work manager and operator).